Technology Bundle ID
TAB-3640

SARS-CoV-2 Neutralizing Antibodies and Synthetic Nanobody Library Using a Humanized Llama Framework Region

Applications
Therapeutics
Research Materials
Diagnostics
Consumer Products
Linked ID
E-172-2021-0
Lead Inventors
Bryan Fleming (NCATS)
Co-Inventors
Alex Renn (NCATS)
Anton Simeonov (NCATS)
Matthew Hall (NCATS)
Ying Fu (NCATS)
ICs
NCATS
NCATS has developed a highly diverse synthetic library that will allow for the rapid identification of novel nanobodies that bind to a wide arrange of target antigens. The humanized framework used to construct the library will facilitate the transition of lead candidates into patient studies. Several highly potent SARS-CoV-2 nanobodies (antibodies) have been identified and are available for further development.

NCATS is actively seeking licensing for the 1) a synthetic library and 2) the potent neutralizing antibodies with activity against SARS-CoV-2.
Commercial Applications
  • Phage panning/Screening the nanobody library to discover novel binders
  • Optimization of SARS-CoV-2 neutralizing antibodies
Competitive Advantages
  • Highly diverse synthetic library.
  • Animal free nanobody discovery.
  • Faster turnaround time than antibody discovery requiring animal immunization.
  • Humanized framework region helps fast track therapeutics into patient trials.

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