Rui Zhao (Regents of the University of Colorado)
Erika Englund (NCATS)
Heide Ford (Regents of the University of Colorado)
Marc Ferrer-Alegre (NCATS)
Noel Southall (NCATS)
Samarjit Patnaik (NCATS)
Seameen Dehdashti (NCATS)
Wei Zheng (NCATS)
This technology includes inhibitors of the Eya phosphatase which can be utilized as anticancer therapy. The Eya proteins are essential co-activators of the Six1 transcription factor, a gene that is abnormally re-expressed in a large percentage of breast cancers. This over-expression plays a causal role in the initiation and metastatic development of breast cancers. The Eya family of proteins was also found to contain a unique haloacid dehalogenase phosphatase domain with protein Tyr phosphatase activity which can potentially play a role in Six1- mediated breast tumorigenesis. Recently, Eya was found to dephosphorylate the histone variant H2AX and direct cells to the DNA repair instead of apoptosis pathway in the event of DNA damage.
- Therapy for Six1-mediated breast cancer.
- Utilized as agents that increase the efficiency of radiation and certain chemotherapy agents.
- One in 8 women will be diagnosed with breast cancer in their lifetime and the Six1 gene is over-expressed in 50% of primary breast tumors and 90% of metastatic lesions; large market share.
- Half of patients with cancer receive radiation therapy and selectively sensitizing tumor tissue by engaging the apoptotic program of a cell is of great interest to the field of radiation oncology.