Technology Bundle ID

Small Molecule Inhibitors of Clk and Dyrk Kinases for Potential Therapeutic Intervention of Down Syndrome, Alzheimer's Disease and Cancer

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Lead Inventors
Jeffrey Aube (The University of Kansas)
Cordelle Tanega (NCATS)
Craig Thomas (NCATS)
Douglas Auld (NCATS)
Frank Schoenen (The University of Kansas)
Min Shen (NCATS)
Thomas Coombs (University of Arkansas)
This technology includes small molecule inhibitors of the cdc2-like kinase (Clk) and Dyrk kinase which can restore splicing outcomes within many dysregulated splicing events potentially reversing phenotypes associated with diseases associated with abnormal splicing. The Clks regulate the alternative splicing of microtubule-associated protein tau and are implicated in frontotemporal dementia and Parkinson's disease through the phosphorylation of splicing factors (SF). DyrklA is proposed to play a critical role in the development of Down Syndrome (DS) due to the location of the DyrklA gene on Chromosome 21 in the Down Syndrome critical region. Inhibitors of Clk and Dyrk isoforms may alter important dysregulated splicing events and could prove to be useful agents in disease phenotypes characterized by abnormal splicing.
Commercial Applications
Treatment for diseases associated with abnormal splicing such as Down Syndrome, Alzheimer’s Disease and cancer.
Competitive Advantages
There are no existing therapies based upon splicing regulation and therapies for diseases such as Down syndrome, Alzheimer's Disease and other diseases associated with incorrect splicing.

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