Technology Bundle ID
TAB-3488

A Scalable Synthesis of Dual-Target Inhibitor of Cannabinoid-1 Receptor and Inducible Nitric Oxide Synthase

Applications
Linked ID
E-098-2019-0
Lead Inventors
Asaf Alimardanov (NCATS)
Co-Inventors
Junfeng Huang (NCATS)
ICs
The present invention is directed to a synthesis of a dual-target inhibitor of cannabinoid-1 (CB1R) receptor and inducible nitric oxide synthase, and more specifically, to an improved process for synthesis of (S,1E,NE)-N-(1-aminoethylidene)-3-(4-chlorophenyl)-4-phenyl-N'-((4-(trifluoromethyl)phenyl)sulfonyl)-4,5-dihydro-1H-pyrazole-1-carboximidamide.
Commercial Applications
This new route and process to synthesis S-MRI1867 without chromatography can be easily adapted to GMP manufacture to produce S-MRI1867 for clinical studies and further commercial production.
Competitive Advantages
This process to produce S-MRI1867 is more time efficient and cost effective. It gives a new version to synthesis the compounds with the core structure similar to S-MRI1867.

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