Technology Bundle ID
TAB-3072

Enhanced Functionalization of Carbon Nanoparticles for Biomedical Applications

Linked ID
E-207-2016-0
Lead Inventors
Keir Neuman (NHLBI)
Co-Inventors
Chandrasekhar Mushti (NHLBI)
Ganesh Shenoy (NHLBI)
Rolf Swenson (NHLBI)
Development Stages
Discovery
ICs
NHLBI
The invention pertains to methods of increasing the density of carboxylic acids on the surface of a carbon nanoparticle that can be functionalized with biologically relevant molecules, such as antibodies or peptides, for biomedical applications. Advantageously, the method could increase functionalization of a nanoparticle by at least about 1x107 functional groups/g of nanoparticle. The method includes contacting an oxygen-containing functional group on a surface of a carbon nanoparticle with a reducing agent to provide a hydroxyl group; reacting the hydroxyl group with a diazoacetate ester in the presence of a transition metal catalyst to provide an ester and then cleaving the ester to provide a carboxylic acid group. The carboxylic acid can further be secondarily functionalized to an acyl chloride, an amide, pegylated, a biotinylate, a folate, a thiol, a maleimide, an active ester, an amine, a chelated gadolinium, an azide, an alkyne, a protein tag, or a dendrimer. Examples of notable nanoparticles that can be derivatized using this method include carbon nanoparticles such as carbon nanotubes, fullerenes, graphenes, graphene oxides, and nanodiamonds; with or without fluorescent properties. Fluorescent nanoparticles are of particular interest for functionalization as they are applicable to both research and diagnostic applications and can be visualized through microscopy.
Commercial Applications
  • Imaging
  • Therapeutics
Competitive Advantages
  • Higher degree of functionalization for carbon nanoparticles

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