Technology Bundle ID
TAB-2907

T Cell-Based Adoptive Transfer Immunotherapy for Polyomavirus-Associated Pathologies

Linked ID
E-166-2014-0
Lead Inventors
Christopher Buck (NCI)
John Barrett (NHLBI)
Co-Inventors
Dhanalakshmi Chinnasamy (NHLBI)
Pawel Muranski (NHLBI)
Development Stages
Development Status
  • Early-stage
  • In vitro data available
ICs
Available for licensing are methods to generate T cells responsive to multiple polyomaviruses. The resulting T cell populations could be useful in treating immunosuppressed individuals with polyomavirus infections or polyomavirus-associated pathologies such as Merkel cell carcinoma (MCC), polyomavirus-associated nephropathy (PVAN), hemorrhagic cystitis, progressive multifocal leukoencephalopathy (PML), and trichodysplasia spinulosa (TS). The methods could also be used to restore polyomavirus-specific immunity in immunocompromised individuals.
Commercial Applications
  • Immunotherapy for immunosuppressed individuals with polyomavirus-associated pathologies.
Competitive Advantages
  • Methods allow development of polyomavirus antigen-specific T cells.

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