Christopher Buck (NCI)
John Barrett (NHLBI)
Dhanalakshmi Chinnasamy (NHLBI)
Pawel Muranski (NHLBI)
- In vitro data available
Available for licensing are methods to generate T cells responsive to multiple polyomaviruses. The resulting T cell populations could be useful in treating immunosuppressed individuals with polyomavirus infections or polyomavirus-associated pathologies such as Merkel cell carcinoma (MCC), polyomavirus-associated nephropathy (PVAN), hemorrhagic cystitis, progressive multifocal leukoencephalopathy (PML), and trichodysplasia spinulosa (TS). The methods could also be used to restore polyomavirus-specific immunity in immunocompromised individuals.
- Immunotherapy for immunosuppressed individuals with polyomavirus-associated pathologies.
- Methods allow development of polyomavirus antigen-specific T cells.