Technology Bundle ID

Nucleic Acid Assays for the Detection and Discrimination of Aspergillus Fungi Species within Biological Samples

Linked ID
Lead Inventors
Christine Morrison (CDC)
Hans Hinrikson (CDC)
Development Stages
Pre-Clinical (in vitro)
Development Status
In vitro data available
This invention relates to assays for the detection and species-specific identification of Aspergillus fungi. Accurate clinical diagnosis of Aspergillus species has become increasingly important as certain species, such as A. terreus and A. fumigatus, are resistant to specific commonly employed antifungal compounds. Most contemporary fungal diagnostic methods are time-consuming and inaccurate. This invention directly addresses those inadequacies by providing a method to rapidly and accurately differentiate all medically important species of Aspergillus based on differences in the DNA sequences of the internal transcribed spacer 1 region of ribosomal DNA.
Commercial Applications
  • Directing antifungal drug therapy for improved patient outcomes
  • Detection, discrimination of Aspergillus species from biological samples
  • Addressing secondary infections of immunosuppressed individuals or asthmatics
Competitive Advantages
  • Easily adapted for use in kits
  • Assay may be used in real-time PCR, in enzyme immunoassays and/or in microarrays
  • High-throughput capable

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