Technology Bundle ID

Species-specific Nucleic Acid Detection Assay for Fungi

Linked ID
Lead Inventors
Christine Morrison (CDC)
Errol Reiss (CDC)
Jong Soo Choi (CDC)
Lilianna Aidorevich (CDC)
Development Stages
Pre-Clinical (in vitro)
Development Status
In vitro data available
This invention pertains to nucleic acid-based assays for the detection of Aspergillus and other filamentous fungi. Assays cover the species-specific detection and diagnosis of infection by Aspergillus, Fusarium, Mucor, Penecillium, Rhizomucor, Absidia, Cunninghamella, Pseudallescheria or Sporthrix in a subject. This can reduce identification time from several days by conventional culture methods to a matter of hours. Furthermore, genus-specific probes are also provided for Aspergillus, Fusarium and Mucor, in addition to an "all-fungus" nucleic acid probe. This technology is readily adaptable as kits used for species-specific identification of opportunistic pathogen infections or possible work/home contamination.
Commercial Applications
  • Directing antifungal drug therapy for improved patient outcomes
  • Detection, discrimination of fungal species from biological samples
  • Addressing secondary infections of immunosuppressed individuals or asthmatics
Competitive Advantages
  • Rapid, sensitive, simple and specific
  • Cost-efficiency compared to culture or sero-diagnostic methods
  • Easily adaptable to kit form
  • High-throughput screening

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