Technology Bundle ID
TAB-2669

Recombinant NIE Antigen from Strongyloides stercoralis

Applications
Research Materials
Linked ID
E-081-2012-0
Lead Inventors
Thomas Nutman (NIAID)
Co-Inventors
Franklin Neva (NIAID)
Ravi Varatharajalu (NIAID)
Development Status
  • Prototype
  • Pilot
  • Pre-clinical
  • In vitro data available
  • In vivo data available (human)
Therapeutic Areas
Infectious Disease
ICs
NIAID
Strongyloides stercoralis is an intestinal nematode endemic that affects an estimated 30 to 100 million people worldwide. Many of these individuals may be asymptomatic for decades. The present invention discloses a NIE recombinant antigen that can be used in improved assays and diagnostics for S. stercoralis infection. The NIE antigen is the only one that is non-cross-reactive with sera from humans with other related filaria infections. The NIE antigen can be utilized as a skin test antigen for immediate hypersensitivity as well as for use in ELISA or other assays.
Commercial Applications
  • Assays and diagnostics for S. stercoralis infection
Competitive Advantages
  • Only non-cross-reactive Strongyloides antigen
  • Use in a variety of formats

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