Technology Bundle ID

Real-Time PCR Assay for Specific Detection of Haemophilus influenzae Serotypes A and B

Linked ID
Lead Inventors
Jennifer Thomas (CDC)
Cynthia Hatcher (CDC)
Leonard Mayer (CDC)
Mary Theodore (CDC)
Raydel Anderson (CDC)
Xin Wang (CDC)
Development Status
  • Early-stage
  • Pre-clinical
  • In vitro data available
Therapeutic Areas
Infectious Disease
Haemophilus influenzae is responsible for life-threatening respiratory infections including meningitis. This assay allows for the qualitative detection of the bacterial meningitis pathogen H. influenzae serotype A (Hia) and serotype B (Hib) in fluid samples, without detecting any of the other serotypes of H. influenzae. This invention is capable of detecting even the very small numbers of Hia or Hib within clinical specimens.
Commercial Applications
  • Meningitis nucleic acid-based diagnostics for testing clinical samples
  • Useful for public health monitoring programs
  • Surveillance of circulating H. influenzae serotypes
Competitive Advantages
  • Easily adapted to a real-time PCR assay (monoplex or multiplex) kit
  • Rapid, accurate and specific, especially when compared to sero-diagnostic approaches
  • No further testing need, presently ready for commercialization

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