Technology Bundle ID

Real-time PCR Assay for Detection of Pneumococcal DNA and Diagnosis of Pneumococcal Disease

Linked ID
Lead Inventors
Maria Da Gloria Carvalho (CDC)
Edwin Ades (CDC)
George Carlone (CDC)
Jacquelyn Sampson (CDC)
Karen McCaustland (CDC)
Development Status
  • Pre-clinical
  • In vitro data available
Therapeutic Areas
Infectious Disease
CDC scientists have developed a real-time PCR assay for diagnosing pneumococcal disease using amplification of the bacterial gene encoding pneumococcal surface adhesin A (PsaA). Pneumococcal isolation and identification is often complicated by 1) antimicrobial suppression of growth in culture and 2) contamination by normal flora alpha-streptococci. Further, pneumococcal detection by culture and serological methods can be time-consuming, relatively expensive, laborious and, ultimately, indeterminate. Sensitive and specific assays that can be completed quickly in the clinical laboratory are essential for early diagnosis and effective therapy. This RT-PCR assay provides a tool for quick and accurate diagnosis by physicians and health care technicians and may be useful in evaluating the efficacy of novel pneumococcal vaccines and therapeutics.
Commercial Applications
  • Pneumococcal disease diagnostics and surveillance programs
  • Streptococcus pneumoniae vaccine development and improvementt
  • Evaluation of efficacy of anti-pneumococcal therapeutics
Competitive Advantages
  • Cost-effective
  • Simple to implement
  • Rapid, accurate and objectively conclusive
  • Easily implemented as a kit

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