Conrad Quinn (CDC)
Jan Pohl (CDC)
Jarad Schiffer (CDC)
Pavel Svoboda (CDC)
Shannon Dalton (CDC)
Stephen Soroka (CDC)
- In vitro data available
Bacillus anthracis is a gram-positive, spore-forming bacteria that causes anthrax infection in humans. CDC inventors have identified epitope sequences of B. anthracis protective antigen (PA) that may be useful for development of peptide-based anthrax vaccines. This invention also relates to methods for determining whether post-vaccination protection is achieved. Specifically, this invention relates to a screening method for determining protection against B. anthracis infection that involves testing a biological sample for the presence of antibodies to one or more predefined regions of B. anthracis PA. This technology may be important to any bioterrorism defense strategy.
- Novel anthrax vaccines
- Post-vaccination screening to determine if anthrax protection is achieved
- May require fewer vaccination follow-ups, while present anthrax vaccines require numerous rounds of injections and boosters for full-effectiveness.
- Identified peptide sequences, representing regions of PA, elicit an immune response in primate and human sera studies.