Technology Bundle ID
TAB-2476

Capillary Viscometer for Measuring Viscosity of Macromolecular Solutions of Biological Relevance

Linked ID
E-231-2012-0
Lead Inventors
Allen Minton (NIDDK)
Co-Inventors
Asaf Grupi (NIDDK)
Development Stages
Prototype
Development Status
  • Prototype
  • In vitro data available
ICs
NIDDK
A capillary-based device and system for measuring the rheological properties of solutions of synthetic and biological polymers. The device automatically serially dilutes and varies the flow rate of a sample, permitting measurement of solution viscosity across wide ranges of concentration and shear rate without changing samples. The device can rapidly and accurately assay solute stability, solute-solvent and solute-solute interactions in solutions of proteins and other macromolecules of biotechnological and pharmaceutical interest, as well as solution injectability.
Commercial Applications
  • Rapid characterization of composition-dependent rheological properties of candidate biopharmaceuticals and industrial polymers.
Competitive Advantages
  • Automatic variation of solute concentration
  • Automatic variation of shear rate
  • Direct measurement of solution injectability

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