Technology Bundle ID
TAB-2476

Capillary Viscometer for Measuring Viscosity of Macromolecular Solutions of Biological Relevance

Linked ID
E-231-2012-0
Lead Inventors
Allen Minton (NIDDK)
Co-Inventors
Asaf Grupi (NIDDK)
Development Stages
Prototype
Development Status
  • Prototype
  • In vitro data available
ICs
NIDDK
A capillary-based device and system for measuring the rheological properties of solutions of synthetic and biological polymers. The device automatically serially dilutes and varies the flow rate of a sample, permitting measurement of solution viscosity across wide ranges of concentration and shear rate without changing samples. The device can rapidly and accurately assay solute stability, solute-solvent and solute-solute interactions in solutions of proteins and other macromolecules of biotechnological and pharmaceutical interest, as well as solution injectability.
Commercial Applications
  • Rapid characterization of composition-dependent rheological properties of candidate biopharmaceuticals and industrial polymers.
Competitive Advantages
  • Automatic variation of solute concentration
  • Automatic variation of shear rate
  • Direct measurement of solution injectability

Request More Info

Licensing Contact:
Vladimir Knezevic, M.D.
vlado.knezevic@nih.gov
Phone: 301.443.5560

Intellectual Properties

  • PCT Application PCT/US2013/055786
    Filed on 2013-08-20
  • US Application 14/419,914
    Filed on 2015-02-05
  • US Application 61/691,209
    Filed on 2012-08-20

Publications

  • Grupi A, Minton AP. Capillary viscometer for fully automated measurement of the concentration and shear dependence of the viscosity of macromolecular solutions. Anal Chem. 2012 Dec 18;84(24):10732-6.
    PMID: 23130673
  • Grupi A, Minton AP. Concentration-dependent viscosity of binary and ternary mixtures of nonassociating proteins: measurement and analysis. J Phys Chem B. 2013 Nov 7;117(44):13861-5.
    PMID: 24131130

Collaborations

  • Collaboration Sought

Collaboration Description

  • The National Institute of Diabetes and Digestive and Kidney Diseases is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize automated capillary viscometer. For collaboration opportunities, please contact Allen P. Minton at minton@helix.nih.gov or Asaf Grupi at grupia@gmail.com.
Date Published
Data Source
tts
Data Source ID
TAB-2476