Technology Bundle ID
TAB-2419
Fgfr2 Knockout (Fgfr2tm1Cxd) Mouse Model for Developmental Biology Studies
Applications
Research Materials
Linked ID
E-124-2012-0
Lead Inventors
Chuxia Deng (NIDDK)
Development Status
Pre-clinical
ICs
NIDDK
FGFR2 knockout is an embryonic lethal mutation and blocks limb bud initiation.
Fibroblast Growth Factor Receptor 2 (FGFR2) is a high affinity receptor for several members of the FGF family. The FGFR2 gene was inactivated by deleting the entire immunoglobulin-like domain of the receptor which is critical for FGF binding and FGFR2 activity. Embryos that lack this domain die at E10-11.5 owing to a failure in chorioallantoic fusion or placental formation. The deletion also blocks limb bud initiation, establishing FGFR2 as the major receptor that mediates FGF signals during limb induction.
Fibroblast Growth Factor Receptor 2 (FGFR2) is a high affinity receptor for several members of the FGF family. The FGFR2 gene was inactivated by deleting the entire immunoglobulin-like domain of the receptor which is critical for FGF binding and FGFR2 activity. Embryos that lack this domain die at E10-11.5 owing to a failure in chorioallantoic fusion or placental formation. The deletion also blocks limb bud initiation, establishing FGFR2 as the major receptor that mediates FGF signals during limb induction.
Commercial Applications
- Mouse model to study developmental biology.
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