Technology Bundle ID
TAB-2401

Monoclonal Antibodies Targeting Human DNA Polymerase beta, a DNA Repair Enzyme

Linked ID
E-036-2008-0
Lead Inventors
Samuel Wilson (NIEHS)
Co-Inventors
Rajendra Prasad (NIEHS)
Development Status
  • Early-stage
  • In vitro data available
Disease Areas
ICs
Available for licensing are monoclonal antibodies targeting human DNA polymerase beta (Pol B). Pol B is a constitutively expressed "housekeeping" enzyme that plays a role in base excision repair (BER), a cellular defense mechanism that repairs DNA base damage and loss. Aberrant Pol B expression is associated with genomic instability indicating that Pol B is required for DNA maintenance, replication and recombination.

These antibodies can be utilized to elucidate BER's mechanism of action and Pol B's structure and function. Moreover, the antibodies can be used to detect Pol B in samples with a variety of techniques including immunoblotting, ELISA, immunoprecipitation, and immunohistochemistry.
Commercial Applications
  • Research tool to elucidate the mechanism of base excision repair
  • Research reagents
Competitive Advantages
  • Can be utilized in a variety of applications to study Pol B

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