Technology Bundle ID
TAB-2357

Transgenic Human Interleukin-21 Mouse Model

Applications
Linked ID
E-231-2010-0
Lead Inventors
Warren Leonard (NHLBI)
Co-Inventors
Katsutoshi Ozaki (University of Tokyo)
Development Status
  • Pre-clinical
  • In vivo data available (animal)
ICs
Available for licensing is a mouse model that constitutively expresses human interleukin-21 (IL-21). Traditionally, human IL-21 transgenic mouse models are difficult to produce as those with high IL-21 levels exhibit growth retardation and die before sexual maturity. The investigators generated transgenic mice that express human IL-21, which can stimulate murine cells in vitro thereby providing an accurate model to elucidate IL-21's role in immunity, immune disorders, and cancer.

IL-21 is a type I cytokine whose receptor is expressed on T, B, and natural killer cells. IL-21 has pleiotropic actions ranging from augmenting the proliferation of T cells to driving the differentiation of B cells into memory cells and terminally differentiated plasma cells. Moreover, IL-21 has anti-tumor activity by augmenting natural killer cell activity. This mouse model allows studying human IL-21 in vivo and its role in a variety of diseases such as autoimmunity, immunodeficiency, allergy, and cancer.
Commercial Applications
  • Model to study human IL-21 in vivo
  • Research tool to elucidate IL-21's role in T, B, and natural killer cell function and regulating antibody production
  • Model to study IL-21's pathology in autoimmunity, immunodeficiency, allergy, and cancer
Competitive Advantages
Mouse model that constitutively expresses human IL-21, without the negative side effects of growth retardation and high toxicity present in other human IL-21 transgenic mice.

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