Technology Bundle ID
TAB-2325

mGluR5 Tumor Mouse Model

Applications
Linked ID
E-123-2010-0
Lead Inventors
Katherine Roche (NINDS)
Co-Inventors
Kyu Yeong Choi (NINDS)
Development Status
  • Prototype
  • Pre-clinical
  • In vivo data available (animal)
ICs
Glutamate receptor mGluR5 has been reported to function in the brain. There were no prior reports of it being involved in melanoma. The NIH investigators have discovered that when over expressed in transgenic animals, mGluR5 induces melanoma. The establishment of an mGluR5 tumor mouse model will provide a unique opportunity to help elucidate the mechanisms underlying tumor formation, and allow the study of aggressive melanoma in animals and a screen of potential therapeutics. Such an mGluR5 tumor mouse model is established at the National Institutes of Health and is available for licensing.
Commercial Applications
  • Drug screening for melanoma therapeutics
  • Research Tool
Competitive Advantages
Tumor mouse model only available from the NIH lab.

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