Technology Bundle ID

Improved Standard for Immune System Recovery Assay

Research Materials
Linked ID
Lead Inventors
Daniel Douek (NIAID)
Brenna Hill (NIAID)
Richard Koup (NIAID)
Development Status
Fully developed
Monitoring an immune system that has been depleted by infection (e.g., HIV), chemotherapy, or progenitor cell transplantation is vital to assessing individual’s recovery status. This technology provides a new plasmid standard to be used as part of the existing TREC assay. This new plasmid has a shorter insert than the commercially available one, which means it now matches the PCR product generated in the qPCR reaction in the TREC assay. Additionally, the new plasmid is easier to grow up than the existing standard.
Commercial Applications
  • TREC assay for T cell concentration measurements
Competitive Advantages
  • The insert of standard plasmid is shorter and directly matches the PCR product generated in the qPCR reaction
  • The standard plasmid is easy to grow up

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