Technology Bundle ID
TAB-1932

Polyclonal Antibodies to Thiazide-Sensitive Sodium-Chloride Cotransporter (NCC)

Applications
Research Materials
Linked ID
E-254-2008-0
Lead Inventors
Mark Knepper (NHLBI)
ICs
NHLBI
Antibodies to thiazide-sensitive sodium-chloride cotransporter (NCC), useful for immunoblotting and immunocytochemistry, are available to resell for research purposes. NCC is found on the apical membrane of the distal convoluted tubule, where it is the principal mediator of Na+ and CI- reabsorption in this segment of the nephron. NCC is the target of thiazide diuretics used in the treatment of hypertension. The inventors have developed rabbit polyclonal antibodies directed against a peptide sequence in the C-terminal region of NCC.
Commercial Applications
Western blotting and immunohistochemistry

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