Technology Bundle ID

Mouse Monoclonal Antibodies to MAD1, a Human Spindle Assembly Checkpoint Protein for Maintaining Chromosomal Segregation

Research Materials
Linked ID
Lead Inventors
Kuan-teh Jeang (Estate) (NIAID)
Therapeutic Areas
Scientists at the National Institutes of Health have developed mouse monoclonal antibodies against the human spindle assembly checkpoint protein, MAD1. The spindle assembly checkpoint in mitotic cell division regulates the fidelity of chromosome segregation during cell division. MAD1 is an important component of this checkpoint control, which if compromised, can lead to the initiation of cancer cell growth. These monoclonal antibodies are the first available antibodies against MAD1 and can be used in laboratory research and diagnostics.
Commercial Applications
  • Research tool in various laboratory procedures to identify and detect MAD1
  • Diagnostic tool for aneuploidy, the condition of having an abnormal number of chromosomes, which results in birth and dev delopmental defects, such as Down syndrome

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