Technology Bundle ID
TAB-1421

Neutralizing Monoclonal Antibodies to Botulinum Neurotoxin Type A

Linked ID
E-180-2006-0
Lead Inventors
Zhaochun Chen (NIAID)
Co-Inventors
Robert Purcell (NIAID)
Suzanne Emerson (NIAID)
Research Products
Antibodies
Therapeutic Areas
Immunology
ICs
NIAID
Two chimpanzee mAbs specifically reacted with light chain of the botulinum neurotoxin A and neutralize the toxin in the mouse model. They can be used for emergency prophylaxis and treatment of either naturally acquired or terrorist associated botulism. Since the sequence of chimpanzee immune globulin is virtually identical to that of humans, the MAbs are not expected to have problems in repeated administration as equine antibodies. They can also be used for rapid diagnosis of botulinum neurotoxin A.
Commercial Applications
  • A research material that can be used in the development of assays, validation of products or in quality control.
Competitive Advantages
  • Speed up product development with NIH developed material that has already been tested and validated.

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