Technology Bundle ID
TAB-119

Human T Cell Line Chronically Infected With HIV

Linked ID
E-143-1989-0
Co-Inventors
Douglas Powell (NIAID)
Kathleen Clouse (NIAID)
Therapeutic Areas
Infectious Disease
ICs
NIAID
A stable line of human T cells (ACH-2) was developed in which cells infected chronically with the AIDS virus (HIV) remained nonproductive prior to exposure to phorbol esters or human cytokines. This situation mimics the latent state of HIV and the development of AIDS in humans and indicates that the full-blown disease may be triggered by cellular-derived substances (e.g., cytokines). This is the first description of such a cell line.

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