Technology Bundle ID
TAB-1175

AAV5 Vector for Transducing Brain Cells and Lung Cells

Applications
Therapeutics
Linked ID
E-072-2000-0
Lead Inventors
John Chiorini (NHLBI)
Co-Inventors
Beverly Davidson (EM)
Joseph Zabner (EM)
Robert Kotin (NHLBI)
Therapeutic Areas
Neurology
ICs
NHLBI
The invention described and claimed in this patent application is related to the delivery of heterologous nucleic acids or genes to particular target cells. In particular, the application relates to methods of delivering a heterologous nucleic acid or gene of interest to particular target cells using an Adeno-Associated Virus of serotype 5 (AAV5). The particular target cells identified include the alveolar cells of the lung and cerebellar and ependymal cells of the brain. The methods described herein may be useful in carrying out gene therapy related to diseases of the brain or central nervous system and the respiratory tract.

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