Technology Bundle ID
TAB-1160

Monoclonal Antibody to the Protein NCOA6 (also called ASC-2, AIB-3)

Applications
Research Materials
Linked ID
E-168-2005-0
Lead Inventors
Paul Meltzer (NHGRI)
Therapeutic Areas
Oncology
ICs
NHGRI
The invention relates to monoclonal antibodies that bind to the transcription factor NCOA6 (ASC-2, AIB-3, TRB, TRAP250, NRC). The antibodies have proven successful reagents for Western blotting and for purifying complexes containing NCOA6. The Western blot experiments revealed that NCOA6 is over-expressed in several breast cancer cell lines, and the purification experiments identified a protein complex containing NCOA6 (the ASCOM complex). The monoclonal antibodies may be useful reagents for studying the role of NCOA6 in transcription and for studying the ASCOM complex.

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