The National Institute on Drug Abuse (NIDA), Biomedical Informatics section, developed the Mobile Interconnected Evaluation & Learning (MIEL) as a mobile health application. MIEL is used for real-time communication of patient-reported assessment data associated with automatically collected geolocation data on one side and the user’s enterprise-scale patient record system on the other. The reported data are for treating polydrug substance abuse or other modalities, as well as the associated risky behaviors, and are interconnected to the patient’s electronic health record system managed at the research facilities. This invention addresses the need for real-time integration of the collected data with information already existing in the patients’ clinical research database to apply intelligent decision support systems for delivery of best care and treatment. MIEL addresses this requirement by allowing early reporting of various data related to drug dependence, including but not limited to substance abuse or craving data in addition to psychosocial state of the patients to the researchers and physicians. This enables the provision of information for better designs in future patient-centric research, ultimately helping to improve treatment outcomes adaptable to the changing needs of individuals relevant to exposed risks.