Technology Bundle ID
NCI-E-175-2012

Silica-Coated Nanodiamonds for Imaging and Delivery of Therapeutic Agents

Applications
Diagnostics
Co-Inventors
Keir Neuman (NHLBI)
Martin Brechbiel (NCI)
Development Status
Prototype
ICs
NHLBI
NCI

The NCI Radiation Oncology Branch and the  NHLBI Laboratory of Single Molecule Biophysics seek parties to co-develop fluorescent  nanodiamonds for use as in vivo and in vitro optical tracking probes toward commercialization.  

NCI and NHLBI investigators invented a robust and easily implemented method of synthesizing silica-coated nanodiamonds for imaging and therapeutic applications. A patent estate covering these methods is offered for licensing to commercial entities. The method generally includes coating nanodiamonds with a silica precursor, e.g, tetraethylorthosilicate (TEOS), inside liposomes. The liposomes are then removed to yield a final product that is stable, monodisperse, and easy to functionalize. 

Commercial Applications
  • Imaging
  • Drug delivery
Competitive Advantages
  • Small size
  • Physiologically inert carrier
  • Monodisperse
  • Stable in aqueous solution
  • Readily functionalized
  • Biological activity is determined more efficiently than chemical analysis
  • High Specificity and selectivity

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