Technology Bundle ID
NCI-E-161-2018

Improved CD22 Binders for Effective Immunotherapy Against Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL)

Applications
Therapeutics
Co-Inventors
Dimiter Dimitrov ()
Sneha Ramakrishna ()
Terry Fry ()
Zhongyu Zhu (NCI)
Development Status
Pre-clinical (in vivo)
ICs
NCI

Targeting the CD22 receptor of B-cells with chimeric antigen receptor (CAR)-T cells has been a promising new therapy to treat B-cell malignancies in clinical trials, inducing remission in 70% of patients with relapsed acute lymphoblastic leukemia (ALL). However, diminished CD22 expression on B-cell surface can lead to relapse and decreased remission duration, which may be prevented through increasing CAR-T affinity towards CD22. 
Researchers at the National Cancer Institute (NCI) developed an affinity-matured monoclonal antibody panel including an anti-CD22 antibody variant, L7, displaying a higher affinity against CD22 than the non-affinity matured versions. The inventors at the NCI developed CAR-T cells incorporating the L7 variable fragment and observed prolonged remission using the L7-CAR-T treatment in combination with Bryostatin1-induced CD22 expression in vivo. The L7 antibody can also be used in other antibody-based therapeutics (such as antibody drug conjugates) against B-cell malignancies.

Commercial Applications
  • Adoptive immunotherapy for relapsed / refractory ALL
  • Antibody drug conjugates against relapsed / refractory ALL
  • Treatment of other B-cell malignancies
Competitive Advantages
  • An established, de-risked target as other anti-CD22 targeted therapies have reached and been evaluated in clinical trials
  • Prolonged remission in ALL mouse models
  • High affinity antibodies against CD22 can be used to develop targeted therapies

Request More Info

Licensing Contact: