Technology Bundle ID
NCI-E-031-2022

Mouse Lines with Fluorescently Labelled Membrane Proteins Regulating Cellular Motility and Membrane Trafficking

Applications
Research Materials
Lead Inventors
Roberto Weigert (NCI)
Co-Inventors
Seham Ebrahim (NCI)
Weye Wang (NCI)
Development Status
Pre-clinical (in vivo)
ICs
NCI

Cell motility and membrane trafficking play important roles in regulating cell division, cell migration, cell death and autophagy. Impairment of these processes can result in enhanced cell proliferation and survival and increased migration and invasion leading to cancer. Several proteins involved in cell motility and membrane trafficking have been shown to be dysregulated in various cancers. There is therefore a need for development of animal models for studying the roles of these proteins in cancer and their responses to drug treatment in vivo.
Researchers at the National Cancer Institute (NCI) have developed mouse lines with fluorescently labelled membrane proteins regulating cellular motility and membrane trafficking. These transgenic mouse lines were created by insertion of fluorescent proteins to tag Myosin IIA, Septin 2, Septin 7, Septin 9 and Rab25. They facilitate the study of cell motility and membrane trafficking proteins and their activity during tumor progression in live animal models. 
NCI is seeking licensees for mouse lines with fluorescently labeled membrane proteins regulating cellular motility and cancer progression.

Commercial Applications

Cancer research
Live animal imaging cancer studies
Live animal imaging cancer drug screening

 

Competitive Advantages

Use of neon-Green and pTag-RFP tagging provides a superior means of imaging in vivo over other fluorescent proteins
These mouse lines facilitate live animal imaging studies of cell motility and membrane trafficking proteins
The first available mouse lines for live animal imaging of Septin 2, Septin 7, Septin 9 and Rab25 in vivo

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