Technology Bundle ID
NCI-E-019-2014

Novel Anti-HIV Compounds Using Peptides or Peptide Mimetics

Applications
Lead Inventors
Yun-Xing Wang (NCI)
Co-Inventors
Ina O'Carroll (NCI)
Liu Yu (NCI)
Ping Yu (NCI)
Development Status
Discovery (Lead Identification)
ICs

The subject invention describes a new class of compounds (such as peptides or mimetics) that target viral RNAs and inhibit the viral life cycle by blocking the viral recognition process. More specifically, these compounds are the first against an RNA Target - currently there are no clinical drugs against RNA targets in the treatment of any type of human disease. Anti-HIV drugs currently on the market are complicated by the development of resistance and substantial side-effects; however, these compounds would unlikely develop any side effects because of their very high specificity against only viral RNA. In addition, these compounds may be further linked to a detectable label. Thus, these compounds have the potential to be used as a new class of systemic drugs for the treatment of HIV infection and to be developed into diagnostic kits or devices.

Commercial Applications
  • Anti-viral HIV therapeutic
  • HIV Diagnostic
Competitive Advantages
  • New class of compound
  • Inhibits the viral recognition process and nuclear export activity
  • High specifity only to HIV RNA
  • Ease of permeability through cell membrane because compound is positively charged.

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