Technology ID
TAB-4629

Hybridomas and Mouse Monoclonal Antibodies for Marburg and Lassa Virus Identification

E-Numbers
E-042-2017-0
Lead Inventor
Rollin, Pierre
Lead IC
CDC
Co-Inventors
Nichol, Stuart
ICs
CDC
Applications
Diagnostics
Development Stages
Pre-Clinical (in vitro)
Research Products
Antibodies

This technology includes eight mouse monoclonal antibodies (mAb) and their corresponding hybridomas used for the Enzyme Linked Immunosorbent Assay (ELISA) detection and identification of Marburg (3) and Lassa (5) virus antigens. Lateral flow assays for hemorrhagic fevers are being developed in response to the Ebola outbreak. Our cocktail can identify different proteins for each virus; Marburg viral proteins 35 and 40 (VP35, VP40) and Lassa nucleoprotein (NP) and glycoprotein (G2). All known Marburg and Lassa viruses can be captured in the ELISA assay. These assays are used for detection of virus and antigens in experimental and clinical specimens. These antibodies have potential for use in a lateral flow rapid tests for an easier, low resource identification of infection with Marburg or Lassa viruses.

Commercial Applications
These antibodies have the potential to be used in such products which would be able to detect whether a patient is infected or has been infected with Marburg or Lassa viruses.

Competitive Advantages
There are currently very few monoclonal antibodies targeting Marburg and Lassa viruses commercially available.

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Licensing Contact:
Hurley, Benjamin
benjamin.hurley@nih.gov
Date Published