Technology ID
TAB-4651

Mycoplasma-free Pitman-Moore (PM) Strain Rabies Virus Stocks for Vaccine Manufacturing

E-Numbers
E-099-2018-0
Lead IC
CDC
Co-Inventors
Yang, Yong
Olson, Victoria
Wu, Xianfu
ICs
CDC
Applications
Vaccines­­­
Research Materials
Therapeutic Areas
Infectious Disease
Development Stages
Pre-Clinical (in vitro)

This technology includes clean, mycoplasma-free, rabies virus stocks for use in vaccine manufacturing. Rabies virus causes a nearly uniformly fatal disease, but can be prevented by timely vaccination. An inactivated rabies vaccine for human use was first prepared in cell culture in 1964, using the Pitman-Moore (PM) strain of fixed rabies virus. Typical rabies vaccine virus stocks stored at the Centers for Disease Control are heavily contaminated by mycoplasma, there this stock provides an alternative supply which is free of mycoplasma.

Commercial Applications
Utilized for vaccine manufacturing.

Competitive Advantages
Mycoplasma contamination is a challenge for the vaccine industry.
Licensing Contact:
Hurley, Benjamin
benjamin.hurley@nih.gov