Technology ID
TAB-4519
3D Bioprinting of Cardiac Patch with Anisotropic and Perfusable Architecture for the Repair of Damaged Cardiac Muscle
E-Numbers
E-183-2018-0
Lead Inventor
Zhang, Lijie
Lead IC
NHLBI
Co-Inventors
Cui, Haitao
Huang, Yimin
Applications
Research Materials
Medical Devices
Therapeutic Areas
Cardiology
Development Stages
Pre-Clinical (in vitro)
Research Products
Research Equipment
This technology includes a novel cardiac patch which was 3D printed to repair damaged cardiac tissue. Based on biological and anatomical understanding of myocardial tissue, a novel 3D bioprinting technique was developed to directly fabricate the cellularized and vascularized cardiac patch with anisotropic fiber and perfusable vessel architecture. The design will integrate biomimetic aligned myocardial fibers and perfusable blood vessels to create a thick, functional cardiac patch, suitable for the human heart implantation. Due to the anisotropic contraction properties, it not only provides a physical support to prevent the dilation of heart wall, but also improve the cardiac tissue regeneration.
Commercial Applications
To provide the fabricating service of 3D bioprinting vascularized cardiac patch scaffold.
Competitive Advantages
Current therapeutics, including autografts, allografts, xenografts, and artificial prostheses, have several disadvantages including: donor tissue shortage, immune rejection, anticoagulation therapy, and limited durability; 3D bioprinting is one of the most feasible techniques for creating complicated implants with macro/micro features.
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